What is the predicted function of the Duffy gene?Cell Adhesion MoleculeRNA Polymerase IIMicrofilamentTranscription FactorChemokine Receptor 2. How does the GA(TC)A mutation in the Duffy promoter provide malaria resistance? Plasmodium vivax can't bind to Endothelial cellsPlasmodium vivax can't bind to Blood CellsDuffy has not effect on ma solutionspile.com

Question

student submitted image, transcription available below

What is the predicted function of the Duffy gene?

Cell Adhesion Molecule
RNA Polymerase II
Microfilament
Transcription Factor
Chemokine Receptor

2. How does the GA(T>C)A mutation in the Duffy promoter provide malaria resistance?

Plasmodium vivax can't bind to Endothelial cells
Plasmodium vivax can't bind to Blood Cells
Duffy has not effect on malarial resistance
Reduced Duffy expression is toxic to malarial parasite Plasmodium vivax

3. How does the GA(T>C)A mutation in the Duffy promoter impact Duffy transcription?

The transcription factor that binds the GATA enhance doesn't bind GACA.
GACA enhancer does not release the transcription factor
The mutation from T > C blocks Duffy mRNA splicing.
The mutation from T > C inhibits Duffy mRNA binding to ribosomes

4. The GA(T>C)A mutation in the Duffy promoter impacted expression of Duffy in the following cell types...

Blood cells
Purkinje, Endolthelial, and Blood cells
Endothelial cells
Purkinje cells

5. Based on your genetics background, what does GA(T>C)A mutation in the Duffy promoter alter?

restriction endonuclease site
phosphorylation site
transcription factor or enhancer binding site

Malaria Resistance and the Duffy Antigen

%

of population with Duffy negative RBCs Howes et al., 2011, Nature Communications The Duffy protein is a chemokine receptor expressed on many different types of cells. It is also a receptor for Plasmodium vivax, one of the parasites that invade red blood cells (RBCs) and cause malaria. In parts of Africa, geneticists found that

95%

of the population have Duffy negative RBCs - this confers resistance to malaria in these people. A mutation in the Duffy gene enhancer region was found in the malaria resistant populations.

Accepted Answer

Expert Answer to - What is the predicted function of the Duffy gene?Cell Adhesion MoleculeRNA Polymerase IIMicrofilamen

Answer

Solution for - What is the predicted function of the Duffy gene?Cell Adhesion MoleculeRNA Polymerase IIMicrofilamen

Answer

This an additional answer to - What is the predicted function of the Duffy gene?Cell Adhesion MoleculeRNA Polymerase IIMicrofilamen

(Solved): What is the predicted function of the Duffy gene?Cell Adhesion MoleculeRNA Polymerase IIMicrofilamen ...

View Expert Answer

Expert Answer

Buy This Answer $5

Place Order

We Provide Services Across The Globe