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(Solved): What is the major organic product formed when 2-methylpropanamide is subjected to the conditions of ...
What is the major organic product formed when 2-methylpropanamide is subjected to the conditions of the Hofmann rearrangement in two different solvents? (b) Draw the product formed in aqueous .
Expert Answer
The Hofmann rearrangement is an organic reaction of a primary amide to a primary amine with one fewer carbon atom. The Hofmann rearrangement is an organic reaction used to convert a primary amide to a primary amine using a halogen, base, water, and heat. The reaction begins with deprotonation of the amide by the base to form an anion which then attacks the halogen to form a N-haloamide. The mechanism of Hofmann rearrangement involves oxidation of the nitrogen followed by rearrangement of the carbonyl and nitrogen to give an isocyanate intermediate. The intermediate is then hydrolyzed to give an amine.