(Solved): Short-limb dwarfism in humans is caused by a missense mutation in the human FGFR2 gene resulting in ...

Short-limb dwarfism in humans is caused by a missense mutation in the human FGFR2 gene resulting in a gain of function, constitutively active FGF receptor protein. a) Diagram a knockin construct that could have been used to create the mouse model for achondroplasia shown below. Achondroplastic/dwarfism in the mouse. The dwarf mouse at the right is heterozygous for an FGFR3 allele with the same amino acid sequence as that causing dwarfism in humans. b) Explain how CRISPR/Cas 9 could have been used to produce a mouse model for this condition.