(Solved): Q1. (1.5 points each) Monensin is a sodium/proton ionophore. Figure 1 summarizes the observation th ...

Q1. (1.5 points each) Monensin is a sodium/proton ionophore. Figure 1 summarizes the observation that the neutral complexes of monensin with either a proton or a sodium ion can cross the membrane, while the uncomplexed, negatively charged form cannot. Figure 1: Minesin permeates the membrane when complexed with sodium or proton ions Show that for the full reaction cycle: a) If \( \mathrm{pH}=7 \) is fixed by buffers on both the inside and outside of the membrane vesicles, and if the initial concentrations of sodium are \( \left[N a^{+}\right]_{\text {out }}=20 \mathrm{mM} \), and \( \left[N a^{+}\right]_{\text {in }}=1 \mathrm{mM} \), which direction is the net reaction favorable for? b) Does this reaction affect on membrane potential? Why?