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In multi-step tumorigenesis, what genetic abnormalities constitute the precancer period? Mild gene ...
In multi-step tumorigenesis, what genetic abnormalities constitute the precancer period? Mild genetic abnormality to Carcinoma in situ Initiation to Carcinoma in situ Initiation to severe genetic abnormality Normal to moderate genetic abnormality
In colon cancer, when does the loss of heterozygosity \( (\mathrm{LOH}) \) in chromosome \( 5 q \) (Chr.5q) usually occurs? During normal to hyperplastic conversion During early adenoma to intermediate adenoma conversion During late adenoma to carcinoma conversion During hyperplasia to adenoma conversion