Example An osmotic pump for drug delivery was developed using potassium chloride to serve as both the osmotic agent and the drug model. The semi-permeable membrane has an area of 2.2 cm² and a thickness of 0.25 mm. The system has a permeability coefficient of 2.8 x 10-6 cm²/atm.hr, with an osmotic pressure of 245 atm. The concentration of the saturated drug solution in the drug core layer at 37°C is 330 mg/mL. Calculate the zero-order delivery rate of the drug from this system.

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Example An osmotic pump for drug delivery was developed using potassium chloride to serve as both the osmotic agent and the drug model. The semi-permeable membrane has an area of

2.2 cm^{2}

and a thickness of

0.25 mm

. The system has a permeability coefficient of

2.8 \times 1 0^{? 6}

cm^{2} / atm . hr

, with an osmotic pressure of

245 atm

. The concentration of the saturated drug solution in the drug core layer at

3 7^{?} C

is 330

mg / mL

. Calculate the zero-order delivery rate of the drug from this system.

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