(Solved): Ethanol Alcohol Dehydrogenase NAD NADH+H Aldehyde Dehydrogenase Methanol NAD Alcohol Dehydrogenase ...

Ethanol Alcohol Dehydrogenase NAD NADH+H Aldehyde Dehydrogenase Methanol NAD Alcohol Dehydrogenase NADH+H* Formaldehyde Formaldehyde Dehydrogenase Formic acid Folote Acetaldehyde Glycoaldehyde Aldehyde Dehydrogenase Acetic acid Glycolic acid Thiamine Acetyl Co-A Glyoxylic acid a-hydroxy-B- ketoadipate Pyridoxine Indicates toxic metobolite. Indicates relatively sufer molecule. Modified from Kraut JA and Kurtz I, CIASN 3:208 Oxalic acid Glycine Figure 1. Metabolic pathways for ethanol, methanol and ethylene glycol. Image modified Kraut JA and Kurtz I, CIASN, 2008. A 20-year old male was admitted to the Emergency Department after consuming 'moonshine'. His laboratory results confirmed methanol poisoning and severe metabolic acidosis. Although methanol itself is not particularly toxic, one of its Ethylene glycol NAD* Alcohol Dehydrogenase NADH+H* CO? H?O Figure 1. Metabolic pathways for ethanol, methanol and ethylene glycol. Image modified Kraut JA and Kurtz I, CIASN, 2008. A 20-year old male was admitted to the Emergency Department after consuming 'moonshine'. His laboratory results confirmed methanol poisoning and severe metabolic acidosis. Although methanol itself is not particularly toxic, one of its metabolites formic acid, is highly acidic and toxic to various tissues in the body, and the likely cause of this patient's metabolic acidosis. Formic acid is produced from methanol through a series of enzyme-catalysed reactions. According to Figure 1, formaldehyde is converted to formic acid by which enzyme? O Alcohol dehydrogenase O Formaldehyde dehydrogenase O Aldehyde dehydrogenase O Folate