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Duchenne muscular dystrophy (DMD) is a rare X-linked recessive disorder. Alice is a woman who is c ...
Duchenne muscular dystrophy (DMD) is a rare X-linked recessive disorder. Alice is a woman who is considering having a child. Her mother Betty has a sister Carol, who has a son David affected by DMD. To the right is the pedigree chart of the family, including Alice's maternal grandmother Esther, and grandfather (Betty and Carol's father). D-F David David Carol BC-F Carol Betty Esther Alice ? A-F A-H 1a) Please provide the most likely genotype (XDXD or XDXd for females, XDY or XdY for males) for everyone in the pedigree chart. David's father D-F Esther Betty and Carol's father BC-F Betty Alice's father A-F Alice Alice's husband A-H 1b) Calculate the probability that Alice's first child will have DMD.