(Solved): d. i, for apraclonidine, identify the functional group responsible for the \( \mathrm{PKa} \), and ...

d. i, for apraclonidine, identify the functional group responsible for the \( \mathrm{PKa} \), and draw the predominant structure at systemic \( \mathrm{pH} \), showing resonance structures as appropriate. (2.5 marks) ii. Explain the difference between true and apparent partition coefficient, and calculate (to \( 1 \mathrm{~d}, \mathrm{p} \) ) the log \( P_{\text {the of apraclonidine. (2.5 marks) }} \)