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Although the predominant hemoglobin in newborns is HbF, adult hemoglobin (HbA) is typically expres ...
Although the predominant hemoglobin in newborns is HbF, adult hemoglobin (HbA) is typically expressed as well. Mutant and wild-type HbA variants can be distinguished through isoelectric focusing (IEF) electrophoresis. Shown below is an IEF gel of four samples from newborn patients of an extended family with a history of an E6V mutation in HbA. Which newborn is most likely homozygous for this mutation? A. Patient A(8%) B. Patient B (43\%) C. Patient C (27\%) D. Patient D (21\%)