(Solved): 5. Consider the metabolic pathway of acetaminophen (APAP) in the figure below and answer the questi ...

5. Consider the metabolic pathway of acetaminophen (APAP) in the figure below and answer the questions that follow: Acetaminophen is metabolized to \\( \\mathrm{N} \\)-acetyl-p-benzoquinoneimine (NAPQI) by the inducible metabolizing enzymes CYP2E1 and CYP3A4. i. What effect does NAPQI have on the human body? ii. In an overdose of acetaminophen, what strategy can be used to decrease the amount of NAPQI? iii. Why is it not advisable to drink alcohol when using acetaminophen? iv. Briefly explain CYP2E1 is induced. v. Explain how GSH is synthesized de novo in the body. What enzyme is required conjugate GSH to the NAPQI molecule?