4. Buffering Systems- Bicarbonate The relationship between breathing out CO2? and the bicarbonate buffering system is show above. The total carbonate pool in blood plasma is 0.025M(0.025M=[HCO3?3]+[CO2?]). The pK=6.1 for the dissociation of H2?CO3? to H+and HCO3?.H2?CO3? is readily produced in blood from water and carbon dioxide by carbonic anhydr solutionspile.com

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4. Buffering Systems- Bicarbonate The relationship between breathing out

CO_{2}

and the bicarbonate buffering system is show above. The total carbonate pool in blood plasma is

0.025 M (0.025 M = [HCO_{3}^{3}] + [CO_{2}])

. The

pK = 6.1

for the dissociation of

H_{2} CO_{3}

to

H^{+}

and

HCO_{3} . H_{2} CO_{3}

is readily produced in blood from water and carbon dioxide by carbonic anhydrase. Therefore,

CO_{2}

can be considered the conjugate acid and

HCO_{3}^{2}

its coniugate base. a) What is the ratio of conjugate base to acid

(A ? / HA)

in blood plasma at

pH 7.6

? b) What are the concentrations of

CO_{2}

and

HCO_{3}

under these conditions? c) Under conditions of severe hyperventilation, the

CO_{2}

concentration is suddenly reduced by

50%

. What is the new blood pH? Is this an example of acidosis or alkalosis?

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