(Solved): 26. How does the proteolysis of well-folded proteins under native conditions by thermolysin occur? ...

26. How does the proteolysis of well-folded proteins under native conditions by thermolysin occur? a. The protease can access the peptide backbone in the native state structure b. Global unfolding of the substrate protein is required before proteolysis can occur c. The protease can cleave all forms of a protein (each intermediate of the protein folding landscape) d. Local unfolding of the substrate protein is required before proteolysis can occur e. $A$ and $C$ 1. $B$ and $D$ 27. What are the implications of the findings presented in this study for the understanding of the mechanism of proteasomal degradation? (select all that apply) a. The findings suggest that ubiquitin is more than just a tag b. The findings suggest there is no need for an unstructured region in a substrate protein c. The findings suggest that only ubiquitin's effect on the global folding of a substrate matters for degradation d. The findings suggest that ubiquitin can be necessary and sufficient for degradation of an otherwise well folded substrate e. The findings suggest that there is an additional layer to the ubiquitin code embedded within which substrate lysine ubiquitin is attached